Role of impaired iron transport on exercise performance in heart failure patients

Abstract Aims Impaired iron transport (IIT) occurs frequently in heart failure (HF) patients, even the absence of anaemia and it is associated with a poor quality life prognosis. The impact IIT on exercise capacity, as assessed by cardiopulmonary test (CPET), HF at present unknown. aim this article to evaluate patients performance IIT, defined transferrin saturation (TSAT) <20%. Methods results We collected data 676 hospitalised for HF. All underwent laboratory analysis, cardiac ultrasound, CPET. Patients were grouped presence/absence (haemoglobin <13 <12 g/dL male female, respectively): Group 1 (G1) no anaemia, IIT; 2 (G2) 3 (G3) 4 (G4) IIT. Peak oxygen uptake (peakVO2) reduced from G1 G3 G2 G4 (G1: 1266±497 mL/min, G2: 1011±385 G3: 1041±395 G4: 833±241 mL/min), whereas ventilation carbon dioxide relationship slope (VE/VCO2 slope) increased 31.8±7.5, 34.5±7.4, 36.1±10.2, 37.5±8.4). At multivariate regression peakVO2 independent predictors brain natriuretic peptide (BNP), left ventricular ejection fraction, VE/VCO2 BNP. Conclusions In impairment independently predictor elevated slope, pivotal index Funding Acknowledgement Type funding sources: Private hospital(s). Main source(s): Centro cardiologico Monzino, Italy